2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N17580
    Lyciumin D 150415-40-0
    Lyciumin D acts as an angiotensin-converting enzyme inhibitor and renin inhibitor. Lyciumin D can be used for the research of hypertension.
    Lyciumin D
  • HY-N17611
    5,6,7-Trihydroxy-4'-methoxyflavone 6563-66-2 98%
    5,6,7-Trihydroxy-4'-methoxyflavone (4'-O-Methylscutellarein) is a flavonoid and a weak inhibitor of xanthine oxidase. 5,6,7-Trihydroxy-4'-methoxyflavone possesses antithrombotic and antioxidant activities. 5,6,7-Trihydroxy-4'-methoxyflavone has an IC50 value of 25.29 µM for DPPH free radical scavenging. 5,6,7-Trihydroxy-4'-methoxyflavone can also inhibit H2O2-induced damage to PC12 cells. 5,6,7-Trihydroxy-4'-methoxyflavone is applicable for the research of diseases such as cerebrovascular disorders.
    5,6,7-Trihydroxy-4'-methoxyflavone
  • HY-N17623
    Ainsliaeasin C 1714097-11-6 98%
    Ainsliaeasin C, a 7-hydroxycoumarin derivative, is an orally active anticoagulant agent that can be found in Ainsliaea fragrans. Ainsliaeasin C exerts anticoagulant activity both in vitro and in vivo. Ainsliaeasin C can be used for the research on thrombotic disorders.
    Ainsliaeasin C
  • HY-N17669
    4H-Tomentosin 68776-19-2
    4H-Tomentosin is a mixed-competitive type soluble epoxide hydrolase (sEH) inhibitor with an IC50 of 6.84 μM and a Ki of 7.02 μM. 4H-Tomentosin interacts with sEH by forming hydrogen bonds with Tyr343, Ile363, and Tyr383.
    4H-Tomentosin
  • HY-N17738
    Acetyljujuboside B 194737-13-8 98%
    Acetyljujuboside B is a saponin. Acetyljujuboside B can be isolated from seeds of Zizyphus jujuba Mill. var. spinosa. Acetyljujuboside B inhibits Ca2+ influx. Acetyljujuboside B shows only sustained vasorelaxant effects, with no transient effect on NE-induced vasoconstrictions. Acetyljujuboside B inhibits histamine release from rat peritoneal exudate cells induced by the antigen-antibody reaction.
    Acetyljujuboside B
  • HY-N17816
    Tambulin 571-72-2 98%
    Tambulin is an orally active flavonol compound found in Zanthoxylum armatum. Tambulin can inhibit cell proliferation, induce apoptosis and inhibit ROS production. Tambulin upregulates cleaved caspase-3, cleaved caspase-9, and Bax, downregulates Bcl-2 levels. Tambulin can stimulate glucose-dependent insulin secretion and induce endothelium-independent vasorelaxation. Tambulin binds to succinate dehydrogenase (SDH) (Ki = 11.02 μM) and shows significant ferric reducing power. Tambulin can enhances oxidative stress resistance, reduces, lipofuscin deposits, lipid levels, α-synuclein levels, improves locomotary behavior, and dopamine levels in in age-synchronized L1 hermaphrodite Caenorhabditis elegans models of ageing and Parkinson's disease. Tambulin can be used for the researches of Parkinson's disease, lung squamous cell carcinoma, and diabetes.
    Tambulin
  • HY-N17826
    YM-254891 726188-99-4 98%
    YM-254891 is a YM-254890 (HY-111557) analogue and Gαq/11 inhibitor. YM-254891 can be isolated from the fermentation broth of Chromobacterium sp. QS3666. YM-254891 inhibits ADP-induced platelet aggregation.
    YM-254891
  • HY-N17833
    Actinoside E 1340600-30-7
    Actinoside E (Kaempferol 3-O-2,4'''-acetylrhamninoside) is a flavonoid triglycoside with antioxidant activity. Actinoside E scavenges DPPH, superoxide anion and hydroxyl radicals, and inhibits lipid peroxidation in mouse liver homogenate. Actinoside E can be used in studies related to myocardial ischemia.
    Actinoside E
  • HY-N17892
    Ariskanin A 128397-31-9
    Ariskanin A is a platelet aggregation inhibitor that exists in Aristolochia kankauensis and Aristolochia manshuriensis. Ariskanin A inhibits rabbit platelet aggregation.
    Ariskanin A
  • HY-N17941
    19-Anhydro-4-epirotungenic acid 121467-45-6
    19-Anhydro-4-epirotungenic acid is a triterpenoid compound that can be isolated from the bark of Ilex rotunda Thunb. 19-Anhydro-4-epirotungenic acid shows no activity against ADP-induced platelet aggregation.
    19-Anhydro-4-epirotungenic acid
  • HY-N18066
    Esculeogenin A 854381-37-6 98%
    Esculeogenin A is the sapogenol of tomato saponin Esculeoside A (HY-N18067). Esculeogenin A is an orally active hepatoprotective, hypolipidemic, and antioxidant agent. Esculeogenin A regulates molecular targets like PPARα, SREBP1, Nrf2, NF-κB, ACAT1/ACAT2 to promote hepatic fatty acid oxidation, suppress de novo lipogenesis, enhance antioxidant defense, and inhibit inflammation. Esculeogenin A improves liver function, alleviates hyperlipidemia, and inhibits hepatic steatosis and foam cell formation, preventing nonalcoholic fatty liver disease in high-fat-diet-fed rats and reducing atherosclerotic lesions in apoE-deficient mice. Esculeogenin A can be used for the research of nonalcoholic fatty liver disease, atherosclerosis, and hyperlipidemia.
    Esculeogenin A
  • HY-N18070
    12-Deoxyphorbol-13-isobutyrate-20-acetate 25090-71-5 98%
    12-Deoxyphorbol-13-isobutyrate-20-acetate is a 12-deoxy-phorbol diterpene ester. 12-Deoxyphorbol-13-isobutyrate-20-acetate is a protein kinase C (PKC) agonist that activates protein kinase C to phosphorylate troponin I and troponin T. 12-Deoxyphorbol-13-isobutyrate-20-acetate induces skin irritation and necrosis in mice without cocarcinogenic activity. 12-Deoxyphorbol-13-isobutyrate-20-acetate inhibits Aspergillus carbonarius growth. 12-Deoxyphorbol-13-isobutyrate-20-acetate supports research on heart failure, cardiomyopathies and fungal infection.
    12-Deoxyphorbol-13-isobutyrate-20-acetate
  • HY-N18088
    2-O-(2,4,6-Trihydroxyphenyl)-6,6'-bieckol 89079-38-9
    2-O-(2,4,6-Trihydroxyphenyl)-6,6'-bieckol (Compound 4) is a bispolyphenol. 2-O-(2,4,6-Trihydroxyphenyl)-6,6'-bieckol can be isolated from the brown alga Ecklonia kurome OKAMURA. 2-O-(2,4,6-Trihydroxyphenyl)-6,6'-bieckol exhibits inhibitory activities toward both α2-macroglobulin (α-M) and α-PI, with IC50s of 1.9 μg/mL and 0.7 μg/mL, respectively.
    2-O-(2,4,6-Trihydroxyphenyl)-6,6'-bieckol
  • HY-N18103
    Anhydrohirundigenin 20853-99-0
    Anhydrohirundigenin (Compound 2) is a steroid. Anhydrohirundigenin can be isolated from the roots of Cynanchum stauntonii. Anhydrohirundigenin has no vasodilation activity.
    Anhydrohirundigenin
  • HY-N18260
    Desmodilactone 60010-74-4
    Desmodilactone is a P2Y1R allosteric antagonist. Desmodilactone can be used for the research of thrombosis.
    Desmodilactone
  • HY-N18311
    Caragiside B 1300025-60-8 98%
    Caragiside B is an isoflavone glucoside that can be isolated from the whole plant of Caragana densa. Caragiside B inhibits arachidonic acid (HY-109590)-induced platelet aggregation by interfering with platelet aggregation pathways.
    Caragiside B
  • HY-N18377
    Moldapyranone A 2781876-25-1
    Moldapyranone A (formula I) is a pyrone compound with a significant effect on up-regulating the expression of KLF2. Moldapyranone A can be used for the study of cardiovascular disease or anti-inflammatory.
    Moldapyranone A
  • HY-N18471
    5,7-Dihydroxytryptamine 31363-74-3 98%
    5,7-Dihydroxytryptamine (5,7-DHP) is an autofluorescent (λex≈365 nm), selective neurotoxin and a transport substrate for MAO-A and 5-HT. 5,7-Dihydroxytryptamine can specifically target and damage central and peripheral 5-HTergic neurons, while affecting 5-HT-related pathways and neurotransmitter balance. 5,7-Dihydroxytryptamine can be used to establish 5-HTergic neuron injury models for studies on neural development, neurodegenerative diseases, as well as mechanisms related to platelet function and retinal neurons.
    5,7-Dihydroxytryptamine
  • HY-N18694
    Horsechestnut extract 8053-39-2
    Horsechestnut extract may be used in research to alleviate chronic venous insufficiency.
    Horsechestnut extract
  • HY-N18713
    Strawberry, fragaria vesca extract 84929-78-2 98%
    Strawberry, fragaria vesca extract, derived from strawberries, is primarily used in the pharmaceutical field to study various diseases, including cardiovascular diseases, inflammatory diseases, and even certain cancer variants.
    Strawberry, fragaria vesca extract
Cat. No. Product Name / Synonyms Application Reactivity